Sally Letter Adebamowo, Donna Spiegelman, Walter C Willett, Kathryn Yards Rexrode, Organization between intakes regarding magnesium, potassium, and you can calcium supplements and you will chance of stroke: 2 cohorts of us ladies and updated meta-analyses, New Western Diary off Medical Nutrition, Volume 101, Matter six, , Users 1269–1277,
Background: Possible studies on the loved ones out-of magnesium, potassium, and you may calcium supplements intakes which have coronary attack chance try contradictory, also to the degree, the result of a blended mineral diet score was not checked-out.
Objective: I checked-out contacts anywhere between consumption out-of magnesium, potassium, and you will calcium and you may threat of experience heart attack in the 86,149 women in the fresh new Nurses’ Health Investigation (NHS) We and you will 94,715 ladies in the fresh new NHS II.
Design: Contained in this possible cohort investigation, we determined Many hours of stroke from the quintiles out of intake for each and every mineral and a mixed diet plan get of the many step three nutrition by using multivariate Cox proportional possibilities designs. Additionally, i current meta-analyses to the weight loss intakes of those nutrition and you may chance of stroke.
Results: Throughout the pursue-up (30 y in the NHS I; 22 y on the NHS II) a total of 3780 event stroke cases was basically recorded. Pooled multivariate RRs away from full coronary attack for females about higher in contrast to a low quintiles was 0.87 (95% CI: 0.78, 0.97) to possess complete magnesium, 0.89 (95% CI: 0.80, 0.99) to own complete potassium, and you will 0.97 (95% CI: 0.87, 1.09) to own full calcium supplements consumption. Pooled RRs for females in the highest in contrast to the lowest quintiles regarding a blended mineral eating plan get was in fact 0.72 (95% CI: 0.65, 0.81) to own overall heart attack, 0.78 (95% CI: 0.66, 0.92) to possess ischemic coronary attack, and 0.80 (95% CI: 0.61, step one.04) to own hemorrhagic coronary arrest. Regarding the updated meta-analyses of all the prospective degree yet, the fresh new joint RR of total coronary attack are 0.87 (95% CI: 0.83, 0.92) to own an one hundred-mg/d escalation in magnesium intake, 0.91 (95% CI: 0.88, 0.94) to possess a a thousand-mg/d increase in potassium consumption, and 0.98 (95% CI: 0.94, step one.02) to possess a 300-mg/d upsurge in calcium consumption.
Conclusions: A blended nutrient diet score is inversely with the danger of coronary arrest. Highest intakes off magnesium and you can potassium although not calcium was indeed including somewhat of the less danger of stroke in women.
Magnesium is an essential mineral and you may cofactor for >300 enzymatic reactions in the torso ( 1). Magnesium ‘s the next very-numerous intracellular cation close to potassium ( 2). Calcium supplements is the most-plentiful nutrient in the human body. Such as for example magnesium and potassium, calcium is actually vitally in aerobic services ( 3). High slimming down intakes of any of them nutritional elements was said to help you all the way down chance of blood pressure levels ( 4– 7), the principal convertible heart attack exposure factor. But not, never assume all possible training tested new family members anywhere between weight-loss and you will extra consumption ones vitamins and likelihood of stroke in females, and you may results was in fact inconsistent. Possible training in the Europe demonstrated magnesium intake, although not intake away from potassium or calcium, is significantly associated with the less chance of stroke ( 7, 8). In the usa, consumption away from potassium and magnesium, however regarding calcium, was from the quicker stroke exposure for the males ( 9), whereas calcium supplements and potassium intakes, although not magnesium intake, had been associated with the less stroke exposure in women ( 10). In addition to, one to analysis demonstrated no full organization anywhere between these nutritional elements and you may chance of coronary attack ( 11).
The few potential observational training which were presented failed to were follow-upwards beyond fifteen y along with a somewhat few event coronary arrest occurrences, plus in most studies, brand new independent aftereffect of for every single nutrient intake away from drugs and you may stroke systems wasn’t checked. In this post, we provide research to your connection each and every mineral consumption of dieting and supplements with likelihood of complete, ischemic, and you will hemorrhagic incident strokes. On top of that, i hypothesized that a combined eating plan rating of the many step 3 minerals could be associated with the shorter coronary arrest risk because these nutritional elements are present along with her inside the snacks, and you may consumption is highly coordinated. I handled such seeks from inside the Us women that have been implemented prospectively on 2 high cohorts this new Nurses’ Health Research (NHS) 5 I and II.